Approximately one third of patients have developed severe chronic symptoms following mild or severe infection from Long COVID aka Post-Acute Sequelae of Sars-Cov2 (PASC). Common symptoms include cognitive impairment(aka brain fog), insomnia, and mood disorders, with fatigue reported as the most frequent and debilitating symptom. Due to the challenges and difficulty of resolving these post sequelae symptoms, and due to any consensus to how to reverse this disorder, many studies have been undertaken to find relief with atypical therapies many of which treat the brain.
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention with potential as a Long COVID treatment as it modulates brain vascular function, enhances ongoing synaptic plasticity. These effects result in modulation of neural circuits underlying common neurological, cognitive, and psychiatric disorders including depression and anxiety. With a history of tDCS trials for non-COVID-19 patients showing mood and cognitive improvement, tDCS presents a rational approach to consider. Results to date with transcranial Direct Current Stimulation (tDCS) for long COVID find reduced fatigue and improved mood. More studies are needed as it is likely that utilizing a variety of therapies are more likely to result in improving long COVID symptoms. Due to its ease of use and flexibility and low adverse profile tDCS provides one more therapy that can provide a viable option. tDCS sessions last 20 minutes are easily implemented in a flexible at home therapy that is very safe and convenient.