Prolotherapy has been in use for over 50 years and PRP in use for 20 years. Recent headlines have featured the amazing results of professional athletes’ experiences with PRP Therapy. Pro football players Hines Ward and Troy Polamalu of the Pittsburgh Steelers received PRP Therapy after injuries that should have sidelined them for months, but they returned to play in a matter of weeks, winning the Super Bowl. Los Angeles Dodgers pitcher Takashi Saito received PRP Therapy for an elbow condition and returned to play in just a few months, versus up to 14 months that recovery from surgery would have taken. Unprecedented results have also been reported for other professional soccer, baseball, and football players. Although PRP Therapy is relatively new to the field of orthopedics, it has been used for more than 20 years in dentistry, and has been used to promote healing, following jaw reconstruction, and for patients with cancer. Many thousands of patients have been treated with Prolotherapy successfully over the last 50 years in countries all around the world. PRP has been utilized for the last 20 years and has been proven to be an effective regenerative force.